Metabolism/Excretion
Undergoes first-pass metabolism in GI mucosa and liver, 20% excreted unchanged in liver
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
q48h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
q48h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
q48h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: q48h
Supplement For Dialysis [Recommendation Level]: Pd
PD: q48h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: q48h, [B]
References
Taketomo, Hodding, Kraus. Pediatric Dosage Handbook, 13th edition. Lexi-Comp, 2006.