Ifosfamide

Metabolism/Excretion
Broken down by the P450 system in liver to acrolein (bladder irritant) and ifosfamide mustard (active drug)
Plasma Protein Binding %
 
20
 
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
75%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 1 g/m2 followed by dialysis session 6-8 hr later
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [B]
References
Carlson L, Goren MP, Bush DA, Griener JC, Quigley R, Tkaczewski I, et al. Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms&#146; tumor. Cancer Chemother Pharmacol. 1998; 41: 140-6. [PMID: 9443627]