Kidney Disease Program

Metabolism/Excretion

Metabolized in the liver to idarubicinol (active metabolite), excretion is primarily biliary, <6.5% renally.

Plasma Protein Binding %

94-97

Dose For Normal Renal Function

Refer to individual protocols

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

75%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 75%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 75%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 75%, [D]