Fludarabine

Metabolism/Excretion
2-fluoro-ara-A(active) and 2-fluoroadenine-5-triphosphate (inactive), renal excretion ~40%
Plasma Protein Binding %
 
19-29
 
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
80%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
Not recommended
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
Not recommended
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 25%
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not recommended
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 80%, fludarabine clearance appears to be inversely correlated with serum creatinine, a dose of 25 mg/m2/day 5 days, 24% of dose excreted in urine, at higher doses 41-60% excreted in urine, [B]
References
Kielstein JT, Stadler M, Czock D, Keller F, Hertenstein B, Radermacher J. Dialysate concentration and pharmacokinetics of 2F-Ara-A in a patient with acute renal failure. Eur J Haematol. 2005; 74: 533-4. [PMID: 15876260]