Kidney Disease Program

Metabolism/Excretion

Metabolized in liver with biphasic decay, up to 50% of oral and IV dose is excreted in urine

Plasma Protein Binding %

94-98

Dose For Normal Renal Function

Refer to individual protocols

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

50%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 50%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 50%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 75%, dose reduce for hyperbilirubinemia as well, [B]