Metabolism/Excretion
Metabolized in liver and plasma to both active and inactive metabolites
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, dose adjust only for hyperbilirubinemia, [B]
References
Speth PA, van Hoesel QG, Haanen C. Clinical pharmacokinetics of doxorubicin. Clin Pharmacokinet. 1988; 15: 15-31. [PMID: 3042244]