Metabolism/Excretion
Extensive liver metabolism to active daunorubicinol, renal excretion 13-25% as active drug, 40% bile excretion
Plasma Protein Binding %
Unknown, but distributes widely to tissues, large Vd
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
50%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, dose reduce for hyperbilirubinemia as well, [B]