Cytarabine

Metabolism/Excretion
Deactivated by cytidine deaminase primarily in the liver, 80% excretion in urine as metabolites
Plasma Protein Binding %
 
13
 
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Consult pediatric reference
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, increased risk of neurotoxicity is associated with creatinine clearance less than 60 mL/min, the manufacturer states that dose may need to be reduced in patients with liver or kidney failure but does not give specific guidelines, [B]
References
P&#246; schl JM, Klaus G, Querfeld U, Ludwig R, Mehls O. Chemotherapy with cytosine arabinoside in a child with Burkitt&#146; s lymphoma on maintenance hemodialysis and hemofiltration. Ann Hematol. 1993; 67: 37-9. [PMID: 8334197]