Metabolism/Excretion
Prodrug must undergo hydroxyl-ation to form active alkylating mustards, eliminated as unchanged drug (20%) and active metabolites (85-90%) in urine
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
75%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50%, administer dose after dialysis run
Supplement For Dialysis [Recommendation Level]: Pd
PD: 75%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, moderately dialyzable, 20-50%, [B]