Metabolism/Excretion
21-44% excreted in urine
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
30%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 30%
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 50%, assay available at St. Jude’ s, [D]
References
Crews KR, Wimmer PS, Hudson JQ, Howard SC, Ribeiro RC, Razzouk BI. Pharmacokinetics of 2-chlorodeoxyadenosine in a child undergoing hemofiltration and hemodialysis for acute renal failure. J Pediatr Hematol Oncol. 2002; 24: 677-80. [PMID: 12439044]