Metabolism/Excretion
Undergoes non-enzymatic metabolism,50% excreted in urine
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
75%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
75%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
50%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50%, administer dose after dialysis run
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 75%, manufacturer states that renal function must return to normal before administering another dose minimally dialyzable, [B]
Toxicity Notes
Use with caution.