Metabolism/Excretion
Liver metabolism via conjugation with glutathione, excreted in urine 10-50% as metabolites
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, assay and pharmacokinetic adjustments available at the University of Washington, Seattle, [B]
References
Masauzi N, Higa T, Nakagawa S, Yoda Y, Suzuki G, Kobayashi N, et al. Pharmacokinetic study of busulfan in an AML patient treated with regular hemodialysis [Letter]. Ann Hematol. 1998; 77: 293-4. [PMID: 9875669] / Stein J, Davidovitz M, Yaniv I, Ben-Ari J, Gamzu Z, Hoffer E, et al. Accidental busulfan overdose: enhanced drug clearance with hemodialysis in a child with Wiskott-Aldrich syndrome. Bone Marrow Transplant. 2001; 27: 551-3. [PMID: 11313692] / Ullery LL, Gibbs JP, Ames GW, Senecal FM, Slattery JT. Busulfan clearance in renal failure and hemodialysis. Bone Marrow Transplant. 2000; 25: 201-3. [PMID: 10673681]