Kidney Disease Program

Metabolism/Excretion

Extensive hepatic, 70% renal excretion

Plasma Protein Binding %

Dose For Normal Renal Function

2-5yo = 5 mg/day q24h; >5yo = 10 mg/day q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: q24h

Supplement For Dialysis [Recommendation Level]: Pd

PD: q24h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: N/A, [D]