Metabolism/Excretion
Liver P450, 11% renal excretion
Dose For Normal Renal Function
≥ 12 yo = 120-180 mg/day
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
60 mg q24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
60 mgq24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
30 mgq24h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 30 mg q24h
Supplement For Dialysis [Recommendation Level]: Pd
PD: 30 mg q24h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: N/A, [D]