Metabolism/Excretion
Limited hepatic, 70% renally excreted
Dose For Normal Renal Function
<2 yo = 0.25 mg/kg dose q24h; 2-5 yo = 2.5-5 mg/dose q24h; >5 yo = 5-10 mg/kg/day
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
Not recommended
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: N/A, [D]
References
Taketomo, Hodding, Kraus. Pediatric Dosage Handbook, 13th edition. Lexi-Comp, 2006.