Kidney Disease Program

Metabolism/Excretion

Extensive hepatic, minimal renal, no adjustment needed for IHD, unbound Cl reduced 27%, IHD reduces concentration by 20%

Plasma Protein Binding %

80-90

Dose For Normal Renal Function

20-60 mg/kg/day q8-12h; if IV, use q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [B]