Kidney Disease Program

Metabolism/Excretion

Minor hepatic, 70% renal excretion, significantly removed by dialysis

Plasma Protein Binding %

13-17

Dose For Normal Renal Function

3-9 mg/kg/day q8-12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

50%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

50%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

25%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 25%, supplemental dose post hemo needed

Supplement For Dialysis [Recommendation Level]: Pd

PD: 25%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 50%, [D]