Phenytoin

Metabolism/Excretion
Hepatic, renal excretion
Plasma Protein Binding %
 
90, 80 in renal patients
 
Dose For Normal Renal Function
0.5-3 yo = 8-10 mg/kg/day; 4-6 yo = 7.5-9 mg/kg/day; 7-9 yo = 7-8 mg/kg/day; 10-16 yo = 6-7 mg/kg/day in 2-3 divided doses
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, monitor free dilantin serum concentration if possible, [D]