Metabolism/Excretion
Hydrolysis in blood, undergoes glomerular filtration and subsequent parital tubular reabsorption
Dose For Normal Renal Function
5-10 mg/kg/day divided 2-3 per day, up to 60 mg/kg/day divided 2 per day
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
50%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50% q24h, supplemental dose post hemo run
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 50%, [B] Patsalos PN. Clinical pharmacokinetics of levetiracetam. Clin Pharmacokinet. 2004; 43: 707-24. [PMID: 15301575]