Metabolism/Excretion
Not metabolized, removed by dialysis
Dose For Normal Renal Function
10-35 mg/kg/day q8h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
75% q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
75% q24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
75% q48h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 75% q48h, give extra dose after each 4 hr hemo run
Supplement For Dialysis [Recommendation Level]: Pd
PD: 75% q48h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 75% q12h, dosing adjusment for renal unsufficiency has not been studied in patients <12 yo, [B]
References
Taketomo, Hodding, Kraus. Pediatric Dosage Handbook, 13th edition. Lexi-Comp, 2006.