Kidney Disease Program

Metabolism/Excretion

Hepatic, 58-61% renal excretion, dialysis patients: T1/2 8-40 hr

Plasma Protein Binding %

Dose For Normal Renal Function

0.25-1 mg/kg dose q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

50%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

25-50%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: Avoid

Supplement For Dialysis [Recommendation Level]: Pd

PD: Avoid

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [D]