Metabolism/Excretion
Reticuloendothelial system, minimal renal excretion
Dose For Normal Renal Function
50-100 U bolus, then 20 U/kg/hr
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
50%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Monitor PTT or ACT, adjust dosage per Pediatric Dosage Handbook, [B]