Kidney Disease Program

Metabolism/Excretion

40% excreted in urine; Cl decreased by 30% if CrCl <30

Plasma Protein Binding %

Minimal

Dose For Normal Renal Function

<2 mo: prophylaxis, 0.75 mg/kg dose q12h, treatment 1.5 mg/kg dose q12h; >2 mo: prophylaxis, 0.5 mg/kg dose q12h, 1 mg/kg q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

70%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

50% q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 50%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 50%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 70%, follow Xa levels, adjust dosage per Pediatric Dosage Handbook, [B]