Metabolism/Excretion
Lyposomal enzyme minimal renal excretion, T1/2 terminal 10 hr
Dose For Normal Renal Function
30,000 U/kg load, then 30,000 U/kg/hr
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
75%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
50%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, monitor coag labs, [D]