Kidney Disease Program

Metabolism/Excretion

Metabolized in liver by glucuronidation, 63-95% urinary excretion

Plasma Protein Binding %

25-38

Dose For Normal Renal Function

Infants >6 wk and children: Oral: 160 mg/m2 dose q8h; IV: continuous, 20 mg/m2/hr; IV intermittent, 120 mg/m2 dose q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

50% q8h unlesscontinuous

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 50% q8h unless continuous

Supplement For Dialysis [Recommendation Level]: Pd

PD: 50% q8h unless continuous

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [B]