Zidovudine

Metabolism/Excretion
Metabolized in liver by glucuronidation, 63-95% urinary excretion
Plasma Protein Binding %
 
25-38
 
Dose For Normal Renal Function
Infants >6 wk and children: Oral: 160 mg/m2 dose q8h; IV: continuous, 20 mg/m2/hr; IV intermittent, 120 mg/m2 dose q6h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
50% q8h unlesscontinuous
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50% q8h unless continuous
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50% q8h unless continuous
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [B]