Metabolism/Excretion
Metabolized intracellularly, HD reduces plasma concentration by 50%
Dose For Normal Renal Function
0.01 mg/kg dose q8h as investigational dosing
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
0.01 mg/kg dose q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
0.01 mg/kg dose q24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
0.01 mg/kg dose q24h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 0.01 mg/kg dose q24h after hemodialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 0.01 mg/kg dose q24h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 0.01 mg/kg dose q12h, [D]