Metabolism/Excretion
Hepatic/intestinalmetabolism, excreted as 88% acylovir in urine, ~33% removed by 4 hr hemodialysis session
Dose For Normal Renal Function
20 mg/kg dose q8h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
20 mg/kg dose q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
20 mg/kg dose q24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
10 mg/kg dose q24h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 10 mg/kg dose q24h, give after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 10 mg/kg dose q24h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: N/A, [D]