Metabolism/Excretion
Metabolizedintracellularly, undergoes glomerular filtration and active tubular secretion, ~30% dialyzed
Dose For Normal Renal Function
<30 kg: 1 mg/kg dose q12h; 30-59 kg: 30 mg q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
<30 kg: 0.5 mg/kg dose q12h,30-59 kg: 15 mg q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
<30 kg: 0.25 mg/kg dose q24h,30-59 kg: 7.5 mg q24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
<30 kg: 0.25 mg/kg dose q24h,30-59 kg: 7.5 mg q24h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: <30 kg: 0.25 mg/kg dose q24h 30-59 kg: 7.5 mg q24h, after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: <30 kg: 0.25 mg/kg dose q24h, 30-59 kg: 7.5 mg q24h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: <30 kg: 0.5 mg/kg dose q12h, 30-59 kg: 15 mg q12h, [B]