Metabolism/Excretion
40-50% removed, 3 hr HD
Dose For Normal Renal Function
IV: 10 mg/kg/day q12h induction, then 5 mg/kg/day q24h; oral: 30 mg/kg dose q8h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
IV: induction = 2.5 mg/kg dose q24h, maintenance = 1.25 mg/kg dose q24h; oral: 100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
IV: induction = 1.25 mg/kg dose q24h, maintenance = 0.625 mg/kg dose q24h; oral: 30 mg/kg dose q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
IV: induction = 1.25 mg/kg dose 3/week, maintenance = 0.625 mg/kg dose 3/week; oral: 30 mg/kg dose q24h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: IV: induction = 1.25 mg/kg dose 3/week, maintenance = 0.625 mg/kg dose 3/week; oral: 30 mg/kg dose 3/week. Give all doses after dialysis.
Supplement For Dialysis [Recommendation Level]: Pd
PD: IV: induction = 1.25 mg/kg dose 3/week, maintenance = 0.625 mg/kg dose 3/week; oral: 30 mg/kg dose 3/week
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: IV: induction = 2.5 mg/kg dose q24h, maintenance = 1.25 mg/ kg dose q24h; oral: 100%, [B]