Metabolism/Excretion
Metabolized intracellularly, excreted unchanged in urine
Dose For Normal Renal Function
Infants (2wk-8mo): 100 mg/m2 dose q12h; children: 120 mg/m2 dose q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
75 mg/m2 dose q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
90 mg/m2 dose q24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
75 mg/m2 dose q24h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 75 mg/m2 dose q24h after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 75 mg/m2 dose q24h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 75 mg/m2 dose q12h, [B]