Dose For Normal Renal Function
20-40 mg/kg/day q12-24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
40 mg 3/week
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
40 mg 3/week
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 40 mg 3/week
Supplement For Dialysis [Recommendation Level]: Pd
PD: 40 mg 3/week
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Should be avoided in patients with CrCl <30 mL/min/ 1.73m2, [D]
References
Ellard GA. Chemotherapy of tuberculosis for patients with renal impairment [Editorial]. Nephron. 1993; 64: 169-81. [PMID: 8321347]