Kidney Disease Program

Metabolism/Excretion

Hepatic P450, <2% excreted in urine

Plasma Protein Binding %

Dose For Normal Renal Function

6 mg/kg dose q12h on first day, then 4 mg/kg dose q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [B]

Toxicity Notes

Must use PO form.