Kidney Disease Program

Metabolism/Excretion

Hepatic, <15% excreted in urine

Plasma Protein Binding %

>99 (albumin)

Dose For Normal Renal Function

<120 days: 10 mg/kg dose q24h, under investigation; >120 days: <8 yo: 3-4 mg/kg dose q24h, >8 yo: 150 mg q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [D]