Kidney Disease Program

Metabolism/Excretion

Hepatic

Plasma Protein Binding %

20-50

Dose For Normal Renal Function

10-15 mg/kg dose q4-6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

q8h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: q8h

Supplement For Dialysis [Recommendation Level]: Pd

PD: q8h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [B]