Kidney Disease Program

Metabolism/Excretion

50-100% dialyzable

Plasma Protein Binding %

2-4

Dose For Normal Renal Function

100-150 mg/kg/day q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

25-37.5 mg/kg dose q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

25-37.5 mg/kg dose q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

25-37.5 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 25-37.5 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 25-37.5 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 25-37.5 mg/kg dose q8h, monitor serum concentrations, [B]