Kidney Disease Program

Metabolism/Excretion

50% plasma concentration decrease during HD

Plasma Protein Binding %

Dose For Normal Renal Function

3-12 mg/kg/day q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

1.5-6 mg/kg/day q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

1.5-6 mg/kg/day q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

1.5-6 mg/kg dose q48h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 1.5-6 mg/kg dose q48h after dialysis

Supplement For Dialysis [Recommendation Level]: Pd

PD: 1.5-6 mg/kg dose q48h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 6 mg/kg dose q24h, [A]