Kidney Disease Program

Metabolism/Excretion

Not removed

Plasma Protein Binding %

80-85

Dose For Normal Renal Function

>8yo: 2-4 mg/kg/day q12-24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

1 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 1 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 1 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [B]