Kidney Disease Program

Metabolism/Excretion

Not removed

Plasma Protein Binding %

24-38

Dose For Normal Renal Function

≤ 5 yo: 5-10 mg/kg dose q12h; >5 yo: 5-10 mg/kg dose q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

All ages: 5-10 mg/kg dose q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

All ages: 5-10 mg/kg dose q48h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: All ages: 5-10 mg/kg dose q48h

Supplement For Dialysis [Recommendation Level]: Pd

PD: All ages: 5-10 mg/kg dose q48h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 10 mg/kg dose q24h, [A]