Kidney Disease Program

Metabolism/Excretion

<10% removed by dialysis

Plasma Protein Binding %

16-43

Dose For Normal Renal Function

20-30 mg/kg/day q12h; for CF: 30 mg/kg/day IV q8-12h or 40 mg/kg/day PO q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

10-15 mg/kg dose q18h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

10-15 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 10-15 mg/kg dose q24h after dialysis

Supplement For Dialysis [Recommendation Level]: Pd

PD: 10-15 mg/kg dose q24h, or IP: LD 50 mg/L, 25 mg/L

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 10-15 mg/kg dose q12h, [A]