Ticarcillin/Clavulanate

Plasma Protein Binding %
 
Tic: 45-65, Clav: 9-30
 
Dose For Normal Renal Function
200-300 mg/kg/day q6h of ticarcillin portion
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
50-75 mg/kg dose q8h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
50-75 mg/kg dose q12h, if hepatic failure also give q24h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50-75 mg/kg dose q12h, if hepatic failure also give q24h
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50-75 mg/kg dose q12h, if hepatic failure also give q24h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 50-75 mg/kg dose q8h, [D]