Kidney Disease Program

Metabolism/Excretion

20-50% dialyzable

Plasma Protein Binding %

45-65

Dose For Normal Renal Function

200-300 mg/kg/day q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

50-75 mg/kg dose q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

50-75 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 50-75 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 50-75 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 50-75 mg/kg dose q8h, [D]