Kidney Disease Program

Metabolism/Excretion

30-40% removed HD

Plasma Protein Binding %

Pip: 22-26, Tazo: 31

Dose For Normal Renal Function

200-300 mg/kg/day q6h of piperacillin portion

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

35-50 mg/kg dose q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

35-50 mg/kg dose q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

35-50 mg/kg dose q8h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 50-75 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 50-75 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 35-50 mg/kg dose q8h, [B]