Piperacillin

Metabolism/Excretion
2-50% dialyzable
Plasma Protein Binding %
 
22
 
Dose For Normal Renal Function
200-300 mg/kg/day q6h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
50-75 mg/kg dose q8h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
50-75 mg/kg dose q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
50-75 mg/kg dose q12h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50-75 mg/kg dose q12h
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50-75 mg/kg dose q12h, or IP: no LD, maint 250 mg/L
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 50-75 mg/kg dose q8h, [A]