Kidney Disease Program

Metabolism/Excretion

Not dialyzable

Plasma Protein Binding %

Dose For Normal Renal Function

50-200 mg/kg/day q4-6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

Only adjust if hepatic and renal failure: 9-25 mg/kg dose q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

Only adjust if hepatic and renal failure: 7.5-15 mg/kg dose q6h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: Only adjust if hepatic and renal failure: 7.5-15 mg/kg dose q6h

Supplement For Dialysis [Recommendation Level]: Pd

PD: Only adjust if hepatic and renal failure: 7.5-15 mg/kg dose q6h, or IP: no LD, maint 125 mg/L

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [B]