Kidney Disease Program

Metabolism/Excretion

40% removed by dialysis

Plasma Protein Binding %

15-18

Dose For Normal Renal Function

100-200 mg/kg/day q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

35-50 mg/kg dose q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

35-50 mg/kg dose q8-12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

35-50 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 35-50 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 35-50 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 35-50 mg/kg dose q6h, [B]