Metabolism/Excretion
30% removed by dialysis
Dose For Normal Renal Function
20-40 mg/kg/day q8h, or 25-45 mg/kg/day q12h of bid formulations, or 80-90 mg/kg/day q12h of 7: 1 formulation (all based on amoxicillin portion)
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
8-20 mg/kg dose (20 mg for high dose) q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
8-20 mg/kg dose (20 mg for high dose) q24h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 8-20 mg/kg dose (20 mg for high dose) q24h after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 8-20 mg/kg dose (20 mg for high dose) q24h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [B]
Toxicity Notes
Do not use the 875 mg tablet for this group.