Dose For Normal Renal Function
10 mg/kg dose q6h or 15 mg/kg dose q8h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
10 mg/kg dose q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
10 mg/kg dose q18-24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
10 mg/kg dose as needed per serum concentration monitoring
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 10 mg/kg dose as needed per serum concentration monitoring
Supplement For Dialysis [Recommendation Level]: Pd
PD: 10 mg/kg dose as needed per serum concentration monitoring, or PD: LD 500 mg/L, maint 30 mg/L
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 10 mg/kg dose q12-24h, monitor serum concentrations, [A]
References
Akil IO, Mir S. Hemodiafiltration for vancomycin overdose in a patient with end-stage renal failure. Pediatr Nephrol. 2001; 16: 1019-21. [PMID: 11793092] / Bunchman TE, Valentini RP, Gardner J, Mottes T, Kudelka T, Maxvold NJ. Treatment of vancomycin overdose using high-efficiency dialysis membranes. Pediatr Nephrol. 1999; 13: 773-4. [PMID: 10603118] / Goebel J, Ananth M, Lewy JE. Hemodiafiltration for vancomycin overdose in a neonate with end-stage renal failure. Pediatr Nephrol. 1999; 13: 423-5. [PMID: 10412863] / Shah M, Quigley R. Rapid removal of vancomycin by continuous veno-venous hemofiltration. Pediatr Nephrol. 2000; 14: 912-5. [PMID: 10975298]