Trimethoprim/Sulfamethoxazole (TMP/SMZ)

Plasma Protein Binding %
 
TMP: 45, SMX: 68
 
Dose For Normal Renal Function
5-20 mg/kg/day q6-12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
5-7.5 mg/kg dose q8h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
5-10 mg/kg dose q12h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
Not recommended, but if used 5-10 mg/kg dose q24h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not recommended, but if used 5-10 mg/kg dose q24h
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not recommended, but if used 5-10 mg/kg dose q24h, or IP: LD 320/1600 mg/L, maint 80/400 mg/L
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 5 mg/kg dose q8h, [B]