Kidney Disease Program

Metabolism/Excretion

Extensively removed

Plasma Protein Binding %

Dose For Normal Renal Function

15-30 mg/kg/day q6-8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

noadjustment

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

4 mg/kg dose every 6 hrs

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 4 mg/kg dose every 6 hrs

Supplement For Dialysis [Recommendation Level]: Pd

PD: 4 mg/kg dose every 6 hrs

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [B]