Kidney Disease Program

Metabolism/Excretion

Hepatic, renal excretion

Plasma Protein Binding %

20-35

Dose For Normal Renal Function

Oral = 0.2-0.5 mg/kg dose q4-6h IR; IV = 0.05-0.2 mg/kg dose q2-4h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

50%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 50%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 50%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 75%, titrate to effect, [B]